Anticancer Molecules from Catharanthus roseus
نویسندگان
چکیده
منابع مشابه
The seco-iridoid pathway from Catharanthus roseus
The (seco)iridoids and their derivatives, the monoterpenoid indole alkaloids (MIAs), form two large families of plant-derived bioactive compounds with a wide spectrum of high-value pharmacological and insect-repellent activities. Vinblastine and vincristine, MIAs used as anticancer drugs, are produced by Catharanthus roseus in extremely low levels, leading to high market prices and poor availab...
متن کاملCrystal structure of akuammicine, an indole alkaloid from Catharanthus roseus
The title compound, C20H22N2O2, an alkaloid isolated from the Madagascar periwinkle, crystallizes in P1 with two independent but closely similar mol-ecules in the unit cell. The mol-ecules are linked into pairs by two N-H⋯O=C hydrogen bonds. The absolute configuration was confirmed by anomalous dispersion effects as S at the 3 and 15 positions, and R at the 7 position.
متن کاملcDNA for S-adenosyl-L-homocysteine hydrolase from Catharanthus roseus.
The majority of the Met synthesized in plants is utilized for methylations performed with S-adenosyl-L-Met. These reactions play a major role in the modification of a large variety of acceptor molecules, such as lipids, polysaccharides, nucleic acids, proteins, and secondary plant products (reviewed by Giovanelli, 1987). The hydrolysis of SAH to adenosine and L-homocysteine by SAH hydrolase is ...
متن کاملCorrigendum: The seco-iridoid pathway from Catharanthus roseus
While this Article was undergoing peer review, Salim et al. (2013), Asada et al. (2013) and Salim et al. (2014) published individual steps of the (seco)iridoid biosynthesis pathway in Catharanthus roseus, including the molecular and biochemical characterization of 7-deoxyloganic acid hydroxylase, 7-deoxyloganetic acid glucosyl transferase and 7-deoxyloganetic acid synthase, which are in agreeme...
متن کاملHypoglycemic Activity of Aqueous Extracts from Catharanthus roseus
Introduction. Catharanthus roseus (L.) is used in some countries to treat diabetes. The aim of this study was to evaluate the hypoglycemic activity of extracts from the flower, leaf, stem, and root in normal and alloxan-induced diabetic mice. Methods. Roots, leaves, flowers, and stems were separated to obtain organic and aqueous extracts. The blood glucose lowering activity of these extracts wa...
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ژورنال
عنوان ژورنال: Indonesian Journal of Pharmacy
سال: 2019
ISSN: 2338-9486,2338-9427
DOI: 10.14499/indonesianjpharm30iss3pp147